The United States continues to lead the world in unicorn creation, far outpacing other regions in the first half of 2025. Of the 83 new unicorns minted globally so far this year, an impressive 52 are based in the U.S., underscoring its dominance in innovation and venture capital activity. This lead reflects the region’s robust tech ecosystem, access to deep funding pools, and a strong pipeline of high-growth startups.
While Europe and Asia have made notable strides, the U.S. remains the epicentre for unicorns, particularly in sectors like AI, defence tech, biotech, fintech, and climate tech.
According to Dealroom data, the top 10 U.S. unicorns of H1 2025 include a mix of breakthrough AI infrastructure companies, next-gen pharma players, and disruptive fintech firms. These sky-high valuations are shaping the technologies and industries of tomorrow at a global scale. Here, we have listed these unicorns from the US.
Thinking Machines Lab
Founder/s: Mira Murati, John Schulman, Barrett Zoph, Lilian Weng, Andrew Tulloch, Luke Metz
Founded year: 2025
Valuation: $12B
Founded by an ex-OpenAI team, Thinking Machines Lab focuses on developing foundational AI models and explainable AI technologies. The company offers generative AI platforms, predictive analytics, custom AI solutions, and AI-powered automation. Its applications span healthcare, finance, manufacturing, and retail. It allows individuals and teams to train, adapt, and safely control how the AI behaves in real-world contexts.
This year, Thinking Machines Lab secured $2 billion in seed funding, achieving a $12 billion valuation. The investment positions the company for significant growth in the AI sector. It will enhance R&D, expand the team, and scale operations, intensifying competition in the AI landscape.
Commonwealth Fusion Systems
Founder/s: Bob Mumgaard, Dan Brunner
Founded year: 2018
Valuation: $9B
Clean energy company Commonwealth Fusion Systems (CFS) develops fusion power to offer a sustainable alternative to fossil fuels. In partnership with MIT, it is building compact, cost-effective tokamaks using advanced magnet technology. These devices aim to achieve sustained nuclear fusion, mimicking the energy process of the sun. CFS is currently focused on its ARC project, which could revolutionise large-scale energy supply for utilities and high-demand industries.
Google has invested $200 million in Commonwealth Fusion Systems and committed to purchasing 200 megawatts of fusion power from its ARC project in Virginia. This backing accelerates CFS’s mission to build a demonstration fusion plant, targeting commercial viability by the early 2030s.
Abridge
Founder/s: Shivdev Rao, Zack Lipton
Founded year: 2018
Valuation: $5.3B
Abridge is a healthcare technology company that uses AI to transform medical conversations into clinical documentation. Its platform allows clinicians to record patient visits, which are converted into structured notes, helping reduce administrative burden and improve care quality. Designed for providers, payers, and pharma, Abridge aims to streamline workflows, boost efficiency, and enhance patient outcomes. The company likely operates on a subscription model tailored for healthcare institutions.
Earlier this year, Abridge landed $300 million in a funding round led by Andreessen Horowitz, bringing its valuation to $5.3 billion. With this funding, the company is well-positioned to scale its impact across health systems, deepening its partnerships with providers and expanding its documentation platform. The backing reflects investor belief in Abridge’s potential to reshape clinical efficiency.
ModMed
Founder/s: Daniel Cane, Michael Sherling
Founded year: 2010
Valuation: $9B
Modernizing Medicine, also known as ModMed, is a healthcare technology company that develops specialty-specific electronic health records (EHR) and integrated software solutions. It focuses on improving clinical efficiency, operational workflows, and patient care. Serving a wide range of medical specialties, ModMed’s cloud-based platform streamlines administrative and clinical tasks, helping physicians manage documentation, billing, scheduling, and patient engagement more effectively within a single, user-friendly system.
Clearlake Capital has acquired a majority stake in Modernizing Medicine in a $5.3 billion deal. The company is expected to accelerate product innovation, expand its customer base, and enhance operational capabilities.
Digital Global Systems
Founder/s: Daniel Carbajal, Fernando Murias
Founded year: 2013
Valuation: $5B
AI-powered spectrum optimisation pioneer Digital Global Systems (DGS) delivers real-time radio frequency (RF) awareness and dynamic spectrum sharing solutions. With over 500 issued and pending patents, DGS supports defence, public safety, and commercial wireless infrastructure. Its technology enables ultra-reliable, low-latency communications essential for 5G and 6G deployment. By addressing interference and spectrum efficiency, DGS is driving innovation in next-generation wireless networks and spectrum management.
Casa del Fuego Family Office has acquired DGS for $5 billion, marking a significant move in wireless innovation. The acquisition is set to accelerate the deployment of next-gen wireless infrastructure and enhance DGS’s growth in spectrum optimisation.
DataDirect Networks
Founder/s: Alex Bouzari, Paul Bloch
Founded year: 1998
Valuation: $5B
Specialising in data storage and management, DataDirect Networks plays a critical role in supporting modern AI applications, including chatbots and autonomous vehicles. Its infrastructure powers high-performance computing needs for major clients like Google Cloud, Ford, xAI, and Nvidia. With a workforce of around 1,000, the firm has built a reputation over two decades for enabling reliable, scalable solutions that meet the immense data demands of AI systems.
Blackstone committed $300 million to bolster this AI data infrastructure provider. The investment in DataDirect Networks signals strong confidence in companies driving AI’s computational backbone and long-term infrastructure scalability.
OpenEvidence
Founder/s: Daniel Nadler, Zachary Ziegler
Founded year: 2021
Valuation: $3.5B
Built exclusively for doctors, OpenEvidence provides an AI-powered medical search engine and generative chatbot that simplifies complex, evidence-based medical information. The platform helps physicians navigate vast clinical literature with speed and accuracy, enabling informed decision-making. Its focus is to enhance its medical knowledge library through trusted content partnerships, making it a go-to clinical intelligence tool in high-stakes environments where clarity and precision are vital.
In a Series B round totaling $210 million, the company attracted investors including Google Ventures, Kleiner Perkins, and Sequoia Capital. This raise brings its total funding to over $300 million and propels its valuation to $3.5 billion. OpenEvidence plans to deepen its medical content partnerships and scale its platform, reinforcing its position in the rapidly growing AI-in-healthcare landscape.
Clay
Founder/s: Varun Anand, Kareem Amin
Founded year: 2017
Valuation: $3B
Empowering sales and marketing teams, OpenEvidence offers AI-driven tools that streamline go-to-market efforts by automating prospect discovery and email personalisation. The platform lets users build and refresh lead lists, and craft tailored outreach messages at scale. It is trusted by thousands of companies, including OpenAI, Canva, and HubSpot, alongside 100+ consulting firms.
Clay has raised a Series C round at a $3 billion valuation, led by CapitalG. Clay plans to continue conducting annual tender offers to reward early employees. Existing backers include Meritech Capital, Boldstart Ventures, Maple VC, First Round Capital, and Box Group.
Function Health
Founder/s: Daniel Swerdlin, Jonathan Swerdlin, Mark Hyman, Mike Nemke, Pranitha Patil, Seth Weisfeld
Founded year: 2022
Valuation: $2.5B
Focused on transforming lifelong wellness, healthtech player Function Health delivers a range of innovative services spanning advanced diagnostics, personalised wellness programs, and modern medical supplies. Its offerings may also include cutting-edge lab equipment and comprehensive testing services, all aimed at improving long-term health outcomes. By integrating technology with preventive care, the company empowers individuals to take control of their health with actionable insights and continuous support throughout their wellness journey.
Last month, Function Health secured $300 million in Series B funding. The capital will be used to enhance its health technology capabilities, expand testing and diagnostics infrastructure, and scale its wellness-focused services.
Celestial AI
Founder/s: David Lazovsky, Preet Virk
Founded year: 2020
Valuation: $2.5B
Celestial AI, a Silicon Valley deep‑tech startup, has developed its Photonic Fabric platform to overcome the limitations of copper interconnects in AI systems. By embedding light-based optical links directly into semiconductor packages, the system enables ultra-high-speed, low-latency, energy-efficient data transfer between AI computing and memory chips. Fully compatible with standard semiconductor processes and 2.5D packaging, it targets hyperscalers, chipmakers, and data centre operators.
In March 2025, Celestial AI raised $250 million in a Series C1 round led by Fidelity Management & Research, with participation from BlackRock, Maverick Silicon, Tiger Global Management, Lip‑Bu Tan, and returning investors including AMD Ventures, Temasek, Porsche SE, Koch Disruptive Technologies, Xora Innovation, and The Engine Ventures. This latest round values the company at $2.5 billion and will support volume production and scale its supply chain to meet rising demand.
